The Extra Strength PLUS was specifically formulated for men and women with Demodex. While targeting the causes of human demodex, the cream relieve facial redness, soothes and calms itchy, irritated demodex prone skin. Apply the Plus on face, chin, forehead, neck and other affected areas of your body. This natural anti-demodex solution can effectively eliminate severe cysts, inflamed cystic acne, painful pimples and blemishes. The Ovante Mite Eliminating Cream is a one-step skin care program. You can apply the cream to a clean face before bedtime or in the morning. Most people use the cream twice a day, but you can decide the amount needed after several days of use. Do a spot test first - start application in a small area so that you know what to expect. During the first few days you may experience some dryness and/or exfoliation of your skin. This is a normal process and will subside. Apply the cream sparingly. More is not better with this product.